Alth Protection and Promotion Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. Received: 2 October 2014 Accepted: 15 October 2014 Published: 4 November 2014 References 1. World Health Organization: Burden of disease from Ambient Air Pollution for 2012 – Summary of Results. In Geneva, Switzerland: WHO; 2014. 2. Schwartz J, Marcus A: Mortality and air pollution in London: a time series analysis. Am J Epidemiol 1990, 131(1):185?94. 3. Schwartz J, Dockery DW: Increased mortality in Philadelphia associated with daily air pollution concentrations. Am Rev Respir Dis 1992, 145(3):600?04. 4. Katsouyanni K, Touloumi G, Spix C, Schwartz J, Balducci F, Medina S, Rossi G, Wojtyniak B, Sunyer J, Bacharova L, Schouten JP, Ponka A, Anderson HR: Short-term effects of ambient sulphur dioxide and particulate matter on mortality in 12 European cities: results from time series data from the APHEA project. Air Pollution and Health: a European Approach. Bmj 1997, 314(7095):1658?663. 5. Katsouyanni K, Touloumi G, Samoli E, Gryparis A, Le Tertre A, Monopolis Y, Rossi G, Zmirou D, Ballester F, Boumghar A, Anderson HR, Wojtyniak B, Paldy A, Braunstein R, Pekkanen J, Schindler C, Schwartz J: Confounding and effect modification in the short-term effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 project. Epidemiology 2001, 12(5):521?31. 6. Kinney PL, Ozkaynak H: Associations of daily mortality and 3-Amino-1H-indazole-4-carbonitrile air pollution in Los Angeles County. Environ Res 1991, 54(2):99?20. 7. Silibello C, Calori G, Brusasca G, Giudici A, Angelino E, Fossati G, 7-Trichloro-8-fluoropyrido[4 Peroni E, Buganza E: Modelling of PM10 concentrations over Milano urban area using two aerosol modules. Environ Model Software 2008, 23(3):333?43. 8. Dockery DW, Pope CA 3rd, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE: An association between air pollution and tert-Butyl (2-bromothiazol-5-yl)carbamate mortality in six U.S. cities. N Engl J Med 1993, 329(24):1753?759. 9. Pope CA 3rd, Thun MJ, Namboodiri MM, Dockery DW, Evans JS, Speizer FE, Heath CW Jr: Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am J Respir Crit Care Med 1995, 151(3 Pt 1):669?74.Additional filesAdditional file 1: Figure S1. Estimated and observed mean PM10 level by place. Figure S2. Data quality control on FARM model estimates (2010?012) according to EU Directive 2008/50/EC. Each point represents PM10 mean concentrations as measured by monitoring stations (x axis) and estimated by FARM model in the corresponding cells (y axis). The cone dotted lines delimit the ?0 range of data quality. Additional file 2: Table S1 PM10 profile (overall PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/17591728 and by season) and selected weather variables (2010?012). All values are calculated at the time of blood sampling. Table S2. Complete list of variables collected for the SPHERE study. Abbreviations BMI: Body Mass Index; CTM: Chemical Transport Models; ECG: Electrocardiogram; EVs: Extracellular vesicles; FEF25: Forced expiratory flows at 25 ; FEF50: Forced expiratory flows at 50 ; FEF75: Forced expiratory flows at 75 ; FEV1: Forced PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/14445666 expiratory volume in one second; FVC: Forced vital capacity; miRNAs: microRNAs; PEF: Peak expiratory flow; PM: Particulate Matter. Competing interests The authors declare that they have no competing interests.Bollati et al. BMC Public Health 2014, 14:1137 http://www.biomedcentral.com/1471-2458/14/Page 12 of10. Pope CA 3rd, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, Godleski JJ: Cardiovascular mort.
